3 edition of Nitrates and nitrate tolerance in angina pectoris found in the catalog.
Nitrates and nitrate tolerance in angina pectoris
Workshop on Nitrate Tolerance (1981 Frankfurt am Main, Germany)
Includes bibliographies and index.
|Statement||M. Kaltenbach [and] G. Kober (eds.).|
|Contributions||Kaltenbach, M. 1928-, Kober, G.|
|LC Classifications||RC685A6 W6 1981|
|The Physical Object|
|Pagination||viii, 171 p. :|
|Number of Pages||171|
As of November , deaths had been associated with the use of Viagra in the U.S. Sixteen of the men who died had also taken a nitrate. Since sexual activity or exercise can precipitate a heart attack in patients with angina pectoris, it may not have been the use of Viagra+ nitrates that was responsible for all of the deaths. However, it. Laursen JB, Boesgaard S, Poulsen HE, Aldershvile J. Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo. Cardiovasc Res. ;31(5) Svendsen JH, Klarlund K, Aldershvile J, Waldorff S. N-acetylcysteine modifies the acute effects of isosorbidemononitrate in angina pectoris patients evaluated by exercise testing.
Nitrate tolerance is a problem which invariably results in the loss of nitrates’ effects on anginal symptoms, exercise capacity, and haemodynamics. 7 Despite a number of different approaches (reviewed in ref. 8), tolerance, with all its implications, remains a limitation to the therapy with nitrates. Get this from a library! Nitrates Updated: Current Use in Angina, Ischemia, Infarction and Failure. [Udho Thadani; Lionel H Opie] -- The chief current clinical indications for the use of nitrates remain ischemic heart disease in all its manifestations, and as adjuvant therapy in .
However, nitrate tolerance develops in most patients during continuous therapy. Provision of a patch-free period is effective in preventing tolerance and a hours-on and hours-off schedule is recommended for prevention of angina in patients with chronic stable angina. Nitrate tolerance and dependence are proved phenomena, yet their impact on the clinical usage of nitrates is not clearly defined. The utility of nitrates, including intravenous nitroglycerin, in the treatment of unstable angina and vasospastic angina is well documented.
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Nitrates and Nitrate Tolerance in Angina Pectoris by M. Kaltenbach, G. Kober,Steinkopff edition, paperbackPages: Nitrates and Nitrate Tolerance in Angina Pectoris [M. Kaltenbach, G. Kober] on *FREE* shipping on qualifying offers.
Nitrates and Nitrate Tolerance in Angina Pectoris by M. Kaltenbach, G. Kober, unknown edition,Pages: The Effect of Long-Acting Nitrates on Ambulatory ECG Changes in Patients with Nitrates and nitrate tolerance in angina pectoris book Pectoris Treated for 1 Week K. Fox, J. Deanfield, C. Wright, P.
Ribeiro, A. Maseri Pages Nitrates and Nitrate Tolerance in Angina Pectoris Enter your mobile number or email address below and we'll send you a link to download the free Kindle App. Then you can start reading Kindle books on your smartphone, tablet, or computer - no Kindle device cturer: Steinkopff.
Many contemporary trials in patients with angina show a rapid loss of the blood pressure lowering effects of nitrates with chronic administration.
However, until recently only an occasional clinical study of patients with cardiovascular disease supported the concept that tolerance to the antianginal actions or beneficial effects of nitrates in Cited by: 6.
Keywords:Stable angina pectoris, organic nitrates, nitrate tolerance, nitrate cross-tolerance. Abstract: Long-acting nitrates are effective antianginal drugs during initial treatment. However, their therapeutic value is compromised by the rapid development of tolerance during sustained therapy, which means that their clinical efficacy is.
Although studies are available that attempt to refute the concept of nitrate-induced tolerance in angina pectoris, well-designed and well-controlled reports are appearing that convincingly establish the occurrence of one or more expressions of tolerance (e.g., shorter duration of action, loss of intensity of effect) with long-term dosing in.
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Review Nitrate tolerance, rebound, and their clinical relevance in stable angina pectoris, unstable angina, and heart failure. Thadani U. Cardiovasc Drugs Ther. Jan; 10(6) [Selection of therapy with nitrates in patients with stable effort angina: results of comparative study of common isosorbide dinitrate and long acting.
When used in long-term prevention of angina pectoris, a daily washout period of 10 h is recommended in order to avoid tolerance. Organic nitrates are also indicated for the treatment of acute cardiac heart failure and in hypertensive urgencies and emergencies.
Get this from a library. Nitrates and Nitrate Tolerance in Angina Pectoris. [M Kaltenbach; G Kober] -- Although nitroglycerin is one of the oldest drugs in cardiology the problem of tolerance is a scientific challenge of today.
The proceedings of this symposium highlight the most re cent questions. The nitrates form a group of drugs that are helpful and essential in the treatment of both angina and heart failure. Nitrates in the Treatment of Angina and Heart Failure Functional mechanism of action – anti-anginal effect.
Nitrates work by causing systemic vasodilation, predominantly venodilation. The venodilation reduces the preload to the. When transdermal GTN is used, tolerance can be avoided by interrupting patches with regular nitrate-free breaks.[63,64] However, this approach can be associated with “rebound” angina due to nitrate withdrawal, and the “zero-hour” effect resulting in worsened exercise tolerance in the morning before patch application.
Rebound angina does. Nitrates are available in different formulations and both short- and long-acting organic nitrates have been shown to be effective in treating angina when used appropriately to avoid nitrate tolerance.
3,6,7 Nitrates are as effective as beta-blockers (BB) and calcium channel blockers (CCB). 8 Sublingual nitroglycerin tablets and oral. Tolerance is the attenuation, or loss, of one or several of the effects of organic nitrates after long term administration.
All organic nitrate regimens using frequent doses of long-acting nitrates (3 or more times daily), continuous delivery systems [transdermal nitroglycerin (glyceryl trinitrate) patches or continuous intravenous infusions of nitroglycerin] or long-acting (sustained release.
Thadani U, Maranda CR, Amsterdam E, et al. Lack of pharmacologic tolerance and rebound angina pectoris during twice-daily therapy with isosorbidemononitrate.
Ann Intern Med ; Gori T, Burstein JM, Ahmed S, et al. Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo study. Nitrates remain among the most commonly used therapeutic agents in cardiology. That they can re lieve pain in angina pectoris has been known at least sincewhen Lauder Brunton described their clinical use.
Now, almost years later, we are constantly learning more about their optimal use. DEFINITION OF ANGINA PECTORIS • Angina pectoris is a Syndrome characterized by sudden severe pressing substernal chest pain or heaviness radiating to the neck, jaw, back and arms.
It is often associated with diaphoresis, tachypnea and nausea • Occurs when there is a deficit in myocardial oxygen supply in relation to myocardial oxygen demand.
Tolerance: Prevention “As is often true in matters of heart, absence makes the heart grow fonder”‐Opie, Interval dosing with eccentric doses providing a nitrate‐free intreval of 10‐12 hours should be observed to reduce or prevent tolerance. • Others (less consistent effects): Co‐therapy.
Nitrates are widely used in anginal prophylaxis. In spite of the fact that the concept of nitrate tolerance was first put forward many years ago, the question of tolerance has remained controversial.
There is widespread agreement that tolerance does occur to the effects of nitrates on arterial press .Nitrate Tolerance Can occur surprisingly quickly, esp in those taking long-acting forms, taking around the clock nitrates, and those taking more than one dosage form.
A regular nitrate free period is arranged to allow certain enzymatic pathways to replenish themselves.Nitrates, although effective at relieving acute anginal pain and well established as a mainstay of chronic angina therapy, may have particular problems.
1, 2 One problem with nitrates is that traditional nitrate use can increase oxidative stress and so induce endothelial dysfunction.